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Marie-Claude Perreault

Assistant Professor of Physiology

Ph.D., Université de Montréal, CANADA

Lab website

Research Interests:

Subcortical descending systems play a central role in the control of movement even when initiated cortically (through corticofugal projections). The goal of our research is to examine how brainstem descending pathways are functionally organized to initiate and control movement in mammals with a particular emphasis on the fast transmitting (glutamatergic) pathways responsible for the initiation of walking.

Research questions are addressed using a multidisciplinary approach that includes optical imaging (single cell calcium imaging in brainstem-spinal cord preparations), in vitro electrophysiology (patch-clamp recording in brainstem/spinal cord slices) and photo-stimulation for functional mapping of synaptic inputs onto spinal cord neurons. Using the neonatal mouse as an animal model also enables the use of optogenetic technology.

Our research focuses on better understanding the normal capabilities of the subcortical descending motor systems and should impel a new appreciation of the potential of these pathways in functional motor recovery after cerebral palsy, stroke and spinal cord injury.

Publications:  PubMed search

Department of Physiology
Emory University School of Medicine
615 Michael Street
Atlanta, GA 30322-3110
Office: 404--727-9897

Email Address:  m-c.perreault@emory.edu