Gandhy Pierre-Louis, PhD
Additional Contact Information
Research Mentor: Kenneth Moberg, Ph.D.
Teaching Mentor: Alexandra Peister, Ph.D., Morehouse College, Department of Biology
B.S., Biology, S.U.N.Y Binghamton, Binghamton, NY, 2008
Ph.D., Developmental Biology, Stanford University, Palo Alto, CA, 2015
FIRST Postdoctoral Fellow, Department of Cell Biology, Emory University School of Medicine, 2015 - 2017
I utilize the genetically tractable model organism Drosophila melanogaster to identify and characterize new components of the Hippo signaling pathway. This conserved pathway regulates tissue size and growth in development, regeneration and is implicated in various cancers. Accordingly, a holistic understanding of this pathway may lead to the discovery of novel cancer therapeutic targets. Recently, our lab has identified a novel co-transcription factor in the pathway, Taiman, which is homologous to the mammalian oncogene Amplified in Breast Cancer-1 (AIB-1). Currently, I am investigating the molecular role of Taiman and its transcriptional targets in development and homeostasis.
Wilson, K.A., Chavda, BJ., Pierre-Louis, G., Quinn, A., Tan-Wilson, A. (2016) Role of vacuolar membrane proton pumps in the acidification of protein storage vacuoles following germination. Plant Physiol Biochem, 104: 242-249. DOI: 10.1016/j.plaphy.2016.03.031
Cho, B., Pierre-Louis, G., Sagner, A., Eaton, S., Axelrod, J.D. (2015) Clustering and negative feedback by endocytosis in planar cell polarity signaling is modulated by ubiquitinylation of prickle. PLoS Genet. 11(5):e1005259. PMCID: PMC4440771