Laurie T. Krug, PhD

Associate Professor of Molecular Genetics and Microbiology

Stony Brook University of New York (SUNY)

Office: 154 Life Sciences Building

Phone: 631.632.9055

Fax: 631.632.9797

Email: laurie.krug@stonybrook.edu

Additional Contact Information

Mailing Address:

Stony Brook University School of Medicine

Department of Molecular Genetics & Microbiology
101 Nicolls Road

Stony Brook, NY 11794-8434

Additional Websites

Biography

Education

B.S., Biology, University of South Carolina, Conway, SC, 1994
Ph.D., Microbiology and Molecular Genetics Program, Emory University, Atlanta, GA, 2001
FIRST Postdoctoral Fellow, Center for Newly Emerging Infectious Diseases, Emory University, 2002-2005

Publications

Vink, E.I., Zheng, Y., Yeasmin, R., Stamminger, T., Krug, L.T., Hearing, P. (2015) Impact of Adenovirus E4-ORF3 Oligomerization and Protein Localization on Cellular Gene Expression. Viruses. 7(5):2428-49.  PMCID: PMC4452913 

Cieniewicz, B., Dong, Q., Li, G., Forrest, J.C., Mounce, B.C., Tarakanova, V.L., van der Velden, A., Krug, L.T. (2015) Murine gammaherpesvirus 68 pathogenesis is independent of Caspase-1/11 in mice and impairs IL-1β production upon extrinsic stimulation in culture. J Virol. 89(13):6562-74. PMCID: PMC4468508 

Minkah, N., Macaluso, M., Oldenburg, D.G., Paden, C.R., White, D.W., McBride, K.M., Krug, L.T. (2015) Absence of the uracil DNA glycosylase of murine gammaherpesvirus 68 impairs replication and delays the establishment of latency in vivo. J Virol. 89(6):3366-79. PMCID: PMC4337548 

Krug, L.T. (2014) Editorial overview: Roseoloviruses: Stopping to smell the roses - the Roseoloviruses have come of age as human pathogens. Curr Opin Virol. 9:vi-vii.  DOI: 10.1016/j.coviro.2014.11.001

Caserta, M.T., Krug, L.T., Pellett, P.E. (2014) Roseoloviruses: unmet needs and research priorities: Perspective. Curr Opin Virol. 9:167-9. DOI: 10.1016/j.coviro.2014.10.005

Krug, L.T., Pellett, P.E. (2014) Roseolovirus molecular biology: recent advances. Curr Opin Virol. 9C:170-177. Review. PMCID: PMC4753783 

Minkah, N., Chavez, K., Shah, P., Maccarthy, T., Chen, H., Landau, N., Krug, L.T. (2014) Host restriction of murine gammaherpesvirus 68 replication by human APOBEC3 cytidine deaminases but not murine APOBEC3. Virology. 454-455:215-26. PMCID: PMC4036618 

Cieniewicz, B., Carpino, N., Krug, L.T. (2014) Enhanced response of T cells from murine gammaherpesvirus 68-infected mice lacking the suppressor of T cell receptor signaling molecules Sts-1 and Sts-2. PLoS One. 9:e90196. PMCID: PMC3938662 

Abernathy, E., Clyde, K., Yeasmin, R., Krug, L.T., Burlingame, A., Coscoy, L., Glaunsinger, B. (2014) Gammaherpesviral gene expression and virion composition are broadly controlled by accelerated mRNA degradation. PLoS Pathog. 10:e1003882. PMCID: PMC3894220

Krug, L.T. (2013) Complexities of gammaherpesvirus transcription revealed by microarrays and RNAseq. Curr Opin Virol. 3:276-84. Review. PMCID: PMC3713182 

Krug, L.T., Evans, A.G., Gargano, L.M., Paden, C.R., Speck, S.H. (2013) The absence of M1 leads to increased establishment of murine gammaherpesvirus 68 latency in IgD-negative B cells. J Virol. 87:3597-604. PMCID: PMC3592133

Cheng, B.Y., Zhi, J., Santana, A., Khan, S., Salinas, E., Forrest, J.C., Zheng, Y., Jaggi, S., Leatherwood, J., Krug, L.T. (2012) Tiled microarray identification of novel viral transcript structures and distinct transcriptional profiles during two modes of productive murine gammaherpesvirus 68 infection. J Virol. 86:4340-57. PMCID: PMC3318610 

Torres-González, E., Bueno, M., Tanaka, A., Krug, L.T., Cheng, D.S., Polosukhin, V.V., Sorescu, D., Lawson, W.E., Blackwell, T.S., Rojas, M., Mora, A.L. (2012) Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis. Am J Respir Cell Mol Biol. 46:748-56. PMCID: PMC3380287

Krug, L.T., Torres-González, E., Qin, Q., Sorescu, D., Rojas, M., Stecenko, A., Speck, S.H., Mora, A.L. (2010) Inhibition of NF-{kappa}B Signaling Reduces Virus Load and Gammaherpesvirus-Induced Pulmonary Fibrosis. Am J Pathol. 177:608-21. PMCID: PMC2913377 

Krug, L.T., Collins, C.M., Gargano, L.M., Speck, S.H. (2009) NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency. J Virol. 83:4732-48. PMCID: PMC2682087

Forrest, J.C.*, Krug, L.T.*, S.H. Speck. (*shared first authorship) (2008) Murine gammaherpesvirus 68 infection of mice: a small animal model for characterizing basic aspects of gamma-herpesvirus pathogenesis. In: Dammania, B., Pipas, J. (Eds.), DNA Tumor Viruses. Springer, New York. In press.

Evans, A.G., Moser, J.M., Krug, L.T., Pozharskaya, V., Mora, A.L., Speck, S.H. (2008) A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology. J Exp Med. 205:669-84. PMCID: PMC2275388

Krug, L.T., Moser, J.M., Dickerson, S.M., Speck, S.H. (2007) Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency. PLoS Pathog. 3:e11. PMCID: PMC1781481 

Moser, J.M., Farrell, M.L., Krug, L.T., Upton, J.W., Speck, S.H. (2006) A gammaherpesvirus 68 gene 50 null mutant establishes long-term latency in the lung but fails to vaccinate against a wild-type virus challenge. J Virol. 80:1592-8. PMCID: PMC1346930 

Klass, C.M., Krug, L.T., Pozharskaya, V.P., Offermann, M.K. (2005) The targeting of primary effusion lymphoma cells for apoptosis by inducing lytic replication of human herpesvirus 8 while blocking virus production. Blood. 105(10):4028-34. PMCID: PMC1895088 

Elliott, J., Goodhew, E.B., Krug, L.T., Shakhnovsky, N., Yoo, L., Speck, S.H. (2004) Variable methylation of the Epstein-Barr virus Wp EBNA gene promoter in B-lymphoblastoid cell lines. J Virol. 78:14062-5. PMCID: PMC533916 

Krug, L.T., Pozharskaya, V.P., Yu, Y., Inoue, N., Offermann, M.K. (2004) Inhibition of infection and replication of human herpesvirus 8 in microvascular endothelial cells by alpha interferon and phosphonoformic acid. J Virol. 78:8359-71.  PMCID: PMC446096 

Pozharskaya, V.P., Weakland, L.L., Zimring, J.C., Krug, L.T., Unger, E.R., Neisch, A., Joshi, H., Inoue, N., Offermann, M.K. (2004) Short duration of elevated vIRF-1 expression during lytic replication of human herpesvirus 8 limits its ability to block antiviral responses induced by alpha interferon in BCBL-1 cells. J Virol. 78:6621-35. PMCID: PMC416518 

Krug, L.T., Inoue, N., Pellett, P.E. (2001) Differences in DNA binding specificity among Roseolovirus origin binding proteins. Virology. 288:145-53. DOI: 10.1006/viro.2001.1066

Krug, L.T., Inoue, N., Pellett, P.E. (2001) Sequence requirements for interaction of human herpesvirus 7 origin binding protein with the origin of lytic replication. J Virol. 75:3925-36. PMCID: PMC114883  

Rapp, J.C., Krug, L.T., Inoue, N., Dambaugh, T.R., Pellett, P.E. (2000) U94, the human herpesvirus 6 homolog of the parvovirus nonstructural gene, is highly conserved among isolates and is expressed at low mRNA levels as a spliced transcript. Virology. 268:504-16.  DOI: 10.1006/viro.1999.0163