Abdel Alli, PhD

Assistant Professor of Physiology and Functional Genomics

University of Florida College of Medicine

Office: MG40B

Phone: 352.273.7877

Email: aalli@ufl.edu

Additional Contact Information

Mailing Address:

University of Florida College of Medicine

Department of Physiology and Functional Genomics

Gainesville, FL 32611

Additional Websites

Biography

Education

B.S., Biology, University of South Florida, Tampa, FL, 2003
M.P.H., Tropical Health/Communicable Disease, University of South Florida College of Public Health, 2004
M.S., Medical Sciences, University of South Florida College of Medicine, 2009
Ph.D., Medical Sciences, University of South Florida College of Medicine, 2009
FIRST Postdoctoral Fellow, Department of Physiology, Emory University School of Medicine, 2010-2014

Research

Dr. Alli is interested in studying the regulation of cell surface receptors and ion channels that are important in health and disease. He completed his postdoc training in the laboratory of Dr. Douglas C. Eaton, Distinguished Professor and Chairman of Physiology at Emory University School of Medicine. Dr. Alli investigated the regulation of the Epithelial Sodium Channel in the distal renal tubule by scaffolding proteins (i.e. MARCKS) and proteases (i.e cathepsin B). 

Dr. Alli has a strong background in epithelial transport and his ability to use the full spectrum of biochemical and physiological methodologies should allow him to identify novel drug targets and molecular mechanisms associated with various diseases. Dr. Alli has broadened his research scope to include studying the regulation of other ion channels in various organs of the body (e.g. heart, lung, and colon) using both cellular and animal models.

Publications

Alli, A.A., Bao, H.F., Liu, B.C., Yu, L., Aldrugh, S., Montgomery, D.S., Ma, H.P., Eaton, D.C. (2015) Calmodulin and CaMKII modulate ENaC activity by regulating the association of MARCKS and the cytoskeleton with the apical membrane. Am J Physiol Renal Physiol. 2015 Jul 1:ajprenal.00631.2014. [Epub ahead of print]

Lu, X.Y., Liu, B.C., Wang, L.H., Yang, L.L., Bao, Q., Zhai, Y.J., Alli, A.A., Thai, T.L., Eaton, D.C., Wang, W.Z., Ma, H.P. (2015) Acute ethanol induces apoptosis by stimulating TRPC6 via elevation of superoxide in oxygenated podocytes. Biochim Biophys Acta. 1853:965-74. PMCID: PMC4441224 

Czikora, I., Alli, A., Bao, H.F., Kaftan, D., Sridhar, S., Apell, H.J., Gorshkov, B., White, R., Zimmermann, A., Wendel, A., Pauly-Evers, M., Hamacher, J., Garcia-Gabay, I., Fischer, B., Verin, A., Bagi, Z., Pittet, J.F., Shabbir, W., Lemmens-Gruber, R., Chakraborty, T., Lazrak, A., Matthay, M.A., Eaton, D.C., Lucas, R. (2014) A Novel TNF-mediated Mechanism of Direct Epithelial Sodium Channel Activation. Am J Respir Crit Care Med. 190:522-32. PMCID: PMC4214088 

Reifenberger, M.S., Yu, L., Bao, H.F., Duke, B.J., Liu, B.C., Ma, H.P., Alli, A.A., Eaton, D.C., Alli, A.A. (2014) Cytochalasin E alters the cytoskeleton and decreases ENaC activity in Xenopus 2F3 cells. Am J Physiol Renal Physiol. 307:F86-95. PMCID: PMC4080154 

Alli, A.A., Brewer, E.M., Montgomery, D.S., Ghant, M.S., Eaton, D.C., Brown, L.A., Helms, M.N. (2014) Chronic ethanol exposure alters the lung proteome and leads to mitochondrial dysfunction in alveolar type 2 cells. Am J Physiol Lung Cell Mol Physiol. 306(11):L1026-35. PMCID: PMC4182291 

Liu, B.C., Song, X., Lu, X.Y., Fang, C.Z., Wei, S.P., Alli, A.A., Eaton, D.C., Shen, B.Z., Li, X.Q., Ma, H.P. (2013) Lovastatin attenuates effects of cyclosporine A on tight junctions and apoptosis in cultured cortical collecting duct principal cells. Am J Physiol Renal Physiol. 305:F304-13. PMCID: PMC3742867 

Yu, L., Cai, H., Yue, Q., Alli, A.A., Wang, D., Al-Khalili, O., Bao, H.F., Eaton, D.C. (2013) WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination. Am J Physiol Renal Physiol. 305(1):F31-41. PMCID: PMC3725674 

Liu, B.C., Lu, X.Y., Song, X., Lei, K.Y., Alli, A.A., Bao, H.F., Eaton, D.C., Ma, H.P. (2013) Scanning ion conductance microscopy: a nanotechnology for biological studies in live cells. Front Physiol. 3:483. PMCID: PMC3544149 

Guo, L.J., Alli, A.A., Eaton, D.C., Bao, H.F. (2013) ENaC is regulated by natriuretic peptide receptor-dependent cGMP signaling. Am J Physiol Renal Physiol. 304(7):F930-7. PMCID: PMC4073950

Alli, A.A., Bao, H.F., Alli, A.A., Aldrugh, Y., Song, J.Z., Ma, H.P., Yu, L., Al-Khalili, O., Eaton, D.C. (2012) Phosphatidylinositol phosphate-dependent regulation of Xenopus ENaC by MARCKS protein. Am J Physiol Renal Physiol. 303(6):F800-11. PMCID: PMC3468524 

Alli, A.A., Song, J.Z., Al-Khalili, O., Bao, H.F., Ma, H.P., Alli, A.A., Eaton, D.C. (2012) Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity. J Biol Chem. 287:30073-83. PMCID: PMC3436264 

Alli, A.A., Gower, W.R. Jr. (2010) Molecular approaches to examine the phosphorylation state of the C type natriuretic peptide receptor. J Cell Biochem. 110:985-94. DOI: 10.1002/jcb.22612

Alli, A.A., Gower, W.R. Jr. (2009) The C type natriuretic peptide receptor tethers AHNAK1 at the plasma membrane to potentiate arachidonic acid-induced calcium mobilization. Am J Physiol Cell Physiol. 297:C1157-67. DOI: 10.1152/ajpcell.00219.2009

Burgess, M.D., Moore, K.D., Carter, G.M., Alli, A.A., Granda, C.S., Ichii, H., Ricordi, C., Gower, W.R. Jr. (2009) C-type natriuretic peptide receptor expression in pancreatic alpha cells. Histochem Cell Biol. 132:95-103.  DOI: 10.1007/s00418-009-0591-3

Eichelbaum, E.J., Sun, Y., Alli, A.A., Gower, W.R. Jr., Vesely, D.L. (2008) Cardiac and kidney hormones cure up to 86% of human small-cell lung cancers in mice. Eur J Clin Invest. 38:562-70. DOI: 10.1111/j.1365-2362.2008.01978.x

Vesely, D.L., Vesely, B.A., Eichelbaum, E.J., Sun, Y., Alli, A.A., Gower, W.R. Jr. (2007) Four cardiac hormones eliminate up to two-thirds of human breast cancers in athymic mice. In Vivo. 21:973-8.

Vesely, B.A., Eichelbaum, E.J., Alli, A.A., Sun, Y., Gower, W.R. Jr., Vesely, D.L. (2007) Four cardiac hormones cause cell death of melanoma cells and inhibit their DNA synthesis. Am J Med Sci. 334:342-9. DOI: 10.1097/MAJ.0b013e318068b627

Vesely, D.L., Eichelbaum, E.J., Sun, Y., Alli, A.A., Vesely, B.A., Luther, S.L., Gower WR Jr. (2007) Elimination of up to 80% of human pancreatic adenocarcinomas in athymic mice by cardiac hormones. In Vivo. 21:445-51.

Eichelbaum, E.J., Vesely, B.A., Alli, A.A., Sun Y, Gower WR Jr, Vesely DL. (2006) Four cardiac hormones eliminate up to 82% of human medullary thyroid carcinoma cells within 24 hours. Endocrine. 30:325-32. DOI: 10.1007/s12020-006-0011-6

Vesely, B.A., Eichelbaum, E.J., Alli, A.A., Sun, Y., Gower, W.R. Jr., Vesely, D.L. (2007) Four cardiac hormones eliminate 4-fold more human glioblastoma cells than the green mamba snake peptide. Cancer Lett. 254:94-101. DOI: 10.1016/j.canlet.2007.02.015

Vesely, B.A., Eichelbaum, E.J., Alli, A.A., Sun, Y., Gower, W.R. Jr., Vesely, D.L. (2006) Urodilatin and four cardiac hormones decrease human renal carcinoma cell numbers. Eur J Clin Invest. 36:810-9.

Gower, W.R., Vesely, B.A., Alli, A.A., Vesely, D.L. (2005) Four peptides decrease human colon adenocarcinoma cell number and DNA synthesis via cyclic GMP. Int J Gastrointest Cancer. 36:77-87.

Vesely, B.A., Alli, A., Song, S., Sanchez-Ramos, J., Fitz, S.R., Gower, W.R. Jr., Vesely, D.L. (2006) Primary malignant tumors of the heart: four cardiovascular hormones decrease the number and DNA synthesis of human angiosarcoma cells. Cardiology. 105:226-33. DOI: 10.1159/000091816

Vesely, B.A., Alli, A.A., Song, S.J., Gower, W.R. Jr., Sanchez-Ramos, J., Vesely, D.L. (2005) Four peptide hormones' specific decrease (up to 97%) of human prostate carcinoma cells. Eur J Clin Invest. 35(11):700-10. DOI: 10.1111/j.1365-2362.2005.01569.x

Vesely, B.A., Song, S., Sanchez-Ramos, J., Fitz, S.R., Alli, A.A., Solivan, S.M., Gower, W.R. Jr., Vesely, D.L. (2005) Five cardiac hormones decrease the number of human small-cell lung cancer cells. Eur J Clin Invest. 35:388-98.

Li, W., Fries, D., Alli, A., Malik, A. (2004) Positively charged sol-gel coatings for on-line preconcentration of amino acids in capillary electrophoresis. Anal Chem. 76:218-27.

Bigham, S., Medlar, J., Kabir, A., Shende, C., Alli, A., Malik, A. (2002) Sol-gel capillary microextraction. Anal Chem. 74:752-61.