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  William S. Agnew

   Visiting Professor of Physiology

B.S. University of California, Los Angeles (zoology,chemistry)

Ph.D., Molecular Biology Institute, University of California, Los Angeles (G. Popjak, advisor)

Research Fellow, Division of Chemistry, California Institute of Technology

Professor, Department of Cellular and Molecular Physiology, Yale University School of Medicine

Professor and Chairman, Department of Physiology, Johns Hopkins University School of Medicine

Professor of Physiology and of Neuroscience, Johns Hopkins University School of Medicine

Visiting Professor, Department of Physiology, Emory University School of Medicine




Research Interests:

We have a long standing interest in the molecular structures and mechanisms of voltage-regulated ion channels that mediate electrical signaling in excitable tissues. Native channel protein complexes, arising from members of superfamilies of ion channel genes in humans and other higher species, are subject to unexpectedly complex variations in structures, mechanisms and physiological roles. These variations are not simply encoded in the gene sequences, but are generated in a cell-specific fashion by intricate post-transcriptional mechanisms of RNA processing. These include RNA editing, alternative RNA splicing and possibly splice variant selection, and alternative patterns of translation. We are currently exploring questions arising from observing this type of post-transcriptional control of protein structure through the development of highly parallel methods for large scale, full-length sequencing of the transcriptomes of complex tissues.

Publications:  PubMed search


Department of Physiology
Emory University School of Medicine
615 Michael Street
Atlanta, GA 30322-3110
Office: 404--727-0631

Email Address:  wagnew@emory.edu